Research / Clinical Summary

Shu Chien, MD, PhD Professor, Bioengineering / Medicine Tumor Growth, Invasion & Metastasis Program Contact by Email

Degrees:
M.D., 1953, Medicine, National Taiwan University, Taipei, Taiwan. Ph.D., 1957, Physiology, Columbia University, New York

Awards:
Member, Academia Sinica, Taipei, ROC, 1976. The First Fahraeus Medal in Clinical Haemorheology, 1981. Landis Award, Microcirculatory Society, 1983. NSF Special Creativity Grant Award, 1985-1988. NIH MERIT Award (National Institute of Heart, Lung, and Blood), 1989-1998. Melville Medal, Am. Soc. Mechanical Engineers, 1990, 1996. Zweifach Award, Vth World Congress for Microcirculation, 1991. Founding Fellow, American Institute of Medical and Biological Engineering, 1992. ALZA Award, Biomedical Engineering Society, 1993. Member, Institute of Medicine, National Academy of Sciences, 1994. Joseph Mather Smith Prize for Distinguished Alumni Research, Columbia University, 1996. Member, National Academy of Engineering, 1997. National Health Medal, Department of Health, Taiwan, ROC, 1998. Ray Daggs Award, American Physiological Society, 1999.

Publications during the Last Three Years:
· Shyy, Y.J.; Lin, M.C.; Han, J.; Lu, Y.; Petrime, M., and Chien, S.: TPA responsive element as a common cis-acting element for mechanical and chemical stimuli. Proc. Nat. Acad. of Sci. U.S.A. 92:8069-8073, 1995.

· Huang, Y.; Rumschitzki, D.; Chien, S., and Weinbaum, S.: A fiber matrix model for the growth of macromolecular leakage spots in the arterial intima. J. Biomech. Engineering 116:430-445, 1995.

· Zhao, Y.; Chien, S., and Skalak, R.: A stochastic model of leukocyte rolling. Biophysical J. 69:1309-1320, 1995.

· Shyy, Y.J.; Li, Y.S.; Lin, M.C.; Chen, W.; Yuan, S.; Usami, S., and Chien, S.: The shear stress-mediated gene expression and the cis-elements involved. J. Biomechanics 28:1451-1457, 1995.

· Wang, D.L., Wung, B.S., Shyy, Y.J., Lin, C.F., Chao, Y.J, Usami, S., and Chien, S.: Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells. Effects of mechanical strain on monocyte adhesion to endothelial cells. Circulation Res. 77:294-302, 1995.

· Skierczynski BA; Skalak R; Chien S. Modeling of molecular mechanisms of cell adhesion. Biochemistry and Cell Biology 73:399-409, 1995.

· Chen, Y.L.; Jan, K.M.; Lin, H, S., and Chien, S.: Ultrastructural studies on macromolecular permeability in relation to endothelial cell turnover. Atherosclerosis 118:89-104, 1996.

· Hansen, J.C.; Skalak, R.; Chien, S., and Hoger, A.: An elastic network model based on the structure of the red blood cell membrane skeleton. Biophys. J. 70:146-166, 1996.

· Li, Y.S., Shyy, J.Y.J., Li, S., Lee, J.D., Su, B., Karin, M., and Chien, S.: The Ras/JNK pathway is involved in shear-induced gene expression. Mol. Cell. Biol. 16:5947-5954, 1996.

· Li, S., Piotrowicz, R.S., Levin, E.G., Shyy, Y.J., and Chien, S.: Fluid shear stress induces the phosphorylation of small heat shock proteins in vascular endothelial cells. Am. J. Physiol. 271:C994-C1000, 1996.

· Hu, Y.L., and Chien, S.: Effects of shear stress on protein kinase C distribution in endothelial cells. J. Histochem. Cytochem. 45:237-249, 1997.

· Lin, M.C., Almus-Jacobs, F., Chen, H.-H., Parry, G.C.N., Mackman, N., Shyy, J. Y.-J., and Chien, S.: Shear stress induction of tissue factor gene expression and phosphorylation of Sp1. J. Clin. Invest. 99:737-744, 1997.

· Yin, Y., Lim, K-H, Weinbaum, S., Chien, S. and Rumschitzki, D.: A model for the initiation and growth of extracellular lipid liposomes in arterial intima. Am. J. Physiol., 272:H1033-1046, 1997.

· Artmann, G.M.; Sung, K.L.; Horn, T.; Whittemore, D.; Norwich, G.; Chien, S.: Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Biophys. J. 72:1434-1441, 1997.

· Huang, Y., Rumschitzki, D. S., Chien, S., and Weinbaum, S.: A fiber matrix model for the filtration through fenestral pores in a compressible arterial intima. Am. J. Physiol., 272:H2023-H2039, 1997.

· Hansen, J.C.; Skalak, R.; Chien, S., and Hoger, A.: Influence of network topology on the elasticity of the red blood cell membrane skeleton. Biophys. J. 72:2369-2381, 1997.

· Chen, Y.L., Jan, K.M., Lin, H.S., and Chien, S.: Relationship between endothelial cell turnover and permeability to horseradish peroxidase. Atherosclerosis, 133:7-14, 1997.

· Shyy, J. Y.-J., and Chien, S.: Role of integrins in cellular responses to mechanical stress and adhesion. Cur. Opin. Cell Biol., 9:707-713, 1997.

· Gregersen, H., Kassab, G., Pallencaoe, E., Lee, C., Chien, S., Skalak, R., and Fung, Y.C.: Morphometry and strain distribution in guinea pig duodenum with reference to the zero-stress state. Am. J. Physiol. 273:G865-G874, 1997.

· Li, S., Kim, M., Schlaepfer, D.D., Hunter, T., Chien, S., and Shyy. J. Y.-J.: The fluid shear stress induction of JNK pathway is mediated through FAK-Grb2-sos. J. Biol. Chem., 272:30455-30622, 1997.

· Jalali, S., Sotoudeh, M., Yuan, S., Chien, S., and Shyy. J. Y.-J.: Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology, 18:227-234, 1997.

· Chien. S., Li, S., and Shyy, J. Y.-J.: Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension, 31(Part 2):162-169, 1998.

· Chiu, J.J., Wang, D.L., Chien, S., Skalak, R., and Usami, S.: Effects of disturbed flows on endothelial cells. J. Biomech. Engineering, 120:2-8, 1998.

· Sotoudeh, M., Jalali, S., Usami, S., Shyy, J. Y.-J., and Chien. S.: A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells. Annals of Biomedical Engineering, 26:181-189, 1998.

· Chien. S., and Shyy, J. Y.-J.: Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol. Bull., 194:390-393, 1998.

· Galbraith, C.G., Skalak, R., and Chien, S.: Shear stress produces three-dimensional remodeling in the endothelial cell cytoskeleton. Cell Motility and Cytoskeleton, 40:317-330, 1998.