Research / Clinical Summary

Claude Sirlin, MD Assistant Professor, Radiology Hematologic Malignancies Program Contact by Email

Dr. Sirlin's primary long-term goal is to develop multimodality contrast agents and imaging protocols for in vivo, non-invasive tumor detection and characterization. Short-term, one of his goals is to develop and test a series of gadolinium-containing, dextran-based macromolecular contrast agents for MR imaging of tumors. Specific projects include:

1) in vitro characterization of these macromolecular agents as a function of backbone size, gadolinium density, and magnetic field strength;

2) in vivo testing of these agents for tumor detection and characterization in animal tumor models;

3) attachment of ligands to the dextran backbone for receptor targeting;

4) attachment of protein transduction domains for intracellular delivery of the agents;

5) development of cleavable spacers to enhance in vivo clearance of the agents;

6) attachment of reporters other than gadolinium (such as technetium and fluorophores) for multi-modality imaging.

Another short-term goal is to optimize clinical MR imaging protocols for 1) HCC detection in patients with cirrhosis, and 2) non-invasive assessment of liver fibrosis and inflammation.

Update Summary via ONcLINE (password required)
Click here to request a new or forgotten password