Medicinal Chemistry

Leader and contact

Wolf Wrasidlo, Ph.D.
Senior Project Scientist
Phone: (858) 534-7080, e-mail: wwrasidlo@ucsd.edu

Service profile

• Organic synthesis of small molecules, in house, or through other sources
• Library design for virtual screening studies and SAR profiling
• Pre-clinical assessment of compounds for biostability and drugability
• Formulation of compounds for pharmaceutical studies
• Assistance with pre-clinical data generation and interpretation, including cell based and in vivo efficacy testing.

Equipment

• Gleason Preparative HPLC for compound purification
• Agilent LC/Mass Spectrometer
• NMR Spectrometer

Overview

This resource provides support for investigators who have conceived new strategies that involve the use of organic compounds for medical use. The service offers in-house expertise to produce such agents from the design stage though the synthesis and characterization on a non-GMP basis. In addition, the resource can formulate compounds for preclinical investigations and lends expertise in the pharmaceutical assessment, including protein binding, metabolic stability and bioavailability.