Research / Clinical Summary

Januario Castro, MD Assistant Clinical Professor, Medicine Hematologic Malignancies Program Contact by Email Visit the Website

Januario E. Castro, M.D. is an Assistant Clinical Professorin the Blood and Marrow Transplantation Division. His main research interest is the study of immune responses against leukemia and lymphoma that can be used for treatment of these clinical conditions. He has found that patients with chronic lymphocytic leukemia (CLL) have a status of immunological anergy that impedes proper antigen presentation and T cells mediated rejection of the leukemia clone(s). He has also observed also that leukemia anergy can be reversed in vitro by activation of CLL B cells via transduction with CD40 ligand (CD154) or by incubation with DNA oligodeoxynucleotides. Currently, Dr. Castro is studying the characteristics of this process in which they break leukemia tolerance and the potential applications in clinical trials.

Dr. Castro completed his Hematology/Oncology fellowship at UCSD, is Board Certified in Internal Medicine and in Hematology and Oncology. He has published four peer reviewed papers, seven abstracts, and seven invited articles, reviews or book chapters.

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