Activity After Breast, Colon, or Rectal Cancer Trial (AACT)
A pilot study to see if telephone counseling can increase physical activity levels in patients who have recently (within the past 12 months) finished treatment for breast cancer or cancer of the colon or rectum.
ACS/UCSD Telephone Counseling Study (Healthy Eating Program Pilot)
The objective of this study was to adapt the highly successful WHEL Study counseling program, so that American Cancer Society (ACS) volunteers could use it to provide dietary counseling to callers to the ACS toll-free helpline. Funded by the American Cancer Society, nearly 700 men and women participated in this study between 2002 and 2005. Preliminary results of data from the pilot phase.
Adenomatous Polyp Prevention: Lifestyle and Eating (APPLE) Study
This randomized clinical feasibility trial investigated the effect of a high-vegetable, high-fiber, high-calcium diet on the risk of developing colon cancer after polyp removal. The study was funded by the National Cancer Institute and involved 100 male and female participants.
CHANGE (Customized Healthy Approach to Nutrition, Goal-Setting, & Exercise) Weight Loss Studies
These studies (CHANGE 102, 102E, and 104) were designed to test the effectiveness of a telephone-administered diet and exercise intervention on weight loss in obese males and females in the placebo arms of three separate clinical trials testing the safety and efficacy of injectable weight loss drug regimens. All three trials involve participants recruited from multiple (18-42) sites across the country. A total of 684 participants were enrolled into CHANGE 102, 274 into CHANGE 102E, and 281 into CHANGE 104. All of these studies are now closed, but data analysis is on-going.
Diet Intervention in Bladder Cancer Study (DIBS)
A pilot study to determine whether a telephone-based dietary counseling intervention will increase cruciferous vegetable intake in patients with superficial bladder cancer.
Low Glycemic Load Diet and Breast Health Study
This pilot study assessed the feasibility of a randomized trial to promote long-term adaptation of a low glycemic load diet among women at high risk for breast cancer. 50 subjects from the Buffalo, NY, area have been recruited and consented by Roswell Park Cancer Institute. The dietary assessment and counseling intervention are handled through UCSD by telephone from the Nutritional Services Shared Resource at the Moores UCSD Cancer Center
MEAL Pilot Study (Men’s Eating and Living Study)
The MEAL Study was a multi-site pilot trial investigating whether our innovative telephone counseling program could help men previously treated for localized, low-risk prostate cancer adopt a cancer-preventive diet. The study enrolled 74 men 50-80 years of age who had been diagnosed with prostate cancer within the previous 48 months. More information on MEAL publications to date.
UCSD/Avon Foundation Telephone Counseling Study (Healthy Eating Program Pilot)
This study provided breast cancer risk assessments to women between the ages of 25 and 70 years, along with education about lowering their breast cancer risk (including modifying their diet). One of the objectives of the study was to determine whether this risk assessment and education motivated women to participate in a healthy eating program. Funded by the Avon Foundation, nearly 180 women participated in this study between 2002 and 2004. Preliminary results of data from the pilot phase of this study.
WHEL Study (Women’s Healthy Eating and Living Study)
This study followed 3,088 breast cancer survivors for 6-11 years. Participants were recruited between 1995 and 2000 from Arizona, California, Oregon, and Texas. The women were randomly assigned to one of two healthy diet groups. Key findings to date include:
- 5-7 servings/day of vegetables and fruits plus 30 minutes/day moderate exercise reduced mortality by 50%. More information here.
- Eating more than 7 servings/day of vegetables and fruits did not reduce recurrence or mortality.
- Women with higher serum carotenoids (indicating more colorful vegetables/fruits) had lower recurrence rates. More information here.
- Higher concentration of bioavailable estrogen contributes to risk for recurrence, and a high-fiber, low-fat diet intervention is associated with reduced serum bioavailable estrogen concentration.